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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name TLR3 siRNA
ncRNA Category siRNA
Disease name age-related macular degeneration (AMD)
Species Mus musculus
Tissues/Cell_line mouse RPE cells
Methods immunohistochemistry, siRNA transfection, qPCR, Western blot
Expression pattern associated
Functional description Poly(I:C) treatment did not increase the viability of TLR3 siRNA transfected cells exposed to oxidative stress, in contrast to poly(I:C) treatment of control siRNA transfected cells.
PubMed ID 23267850
Year 2013
Title Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism.
Drug-related ncRNA NO

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